| PGF and Cytokines | Cell0 Sources | Function and Effects |
| PDGF (AA-BB-AB) | Platelets, endothelial cells, macrophages, smooth muscle cells | Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis |
| TGF (α–β) | Macrophages, Tlymphocytes, keratinocytes | Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation |
| VEGF | Platelets, macrophages, keratinocytes, endothelial cells | Increases angiogenesis and vessel permeability, stimulates mitogenesis for endothelial cells |
| EGF | Platelets, macrophages, monocytes | Proliferation of keratinocytes, fibroblasts, stimulates mitogenesis for endothelial cells |
| (a-b)-FGF | Platelets, macrophages, mesenchymal cells, chondrocytes, osteoblasts | Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts |
| CTGF | Platelets, fibroblasts | Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion |
| IGF-1 | Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix | Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts |
| HGF | Platelets, mesenchymal cells | Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing |
| KGF | Fibroblasts, mesenchymal cells | Regulates epithelial migration and proliferation |
| Ang-1 | Platelets, neutrophils | Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte |
| PF4 | Platelets | Calls leucocytes and regulates their activation. Microbiocidal activities |
| SDF-1α | Platelets, endothelial cells, fibroblasts | Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes |
| TNF | Macrophages, mast cells, T lymphocytes | Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis |
| PGF and Cytokines | Cell0 Sources | Function and Effects |
| PDGF (AA-BB-AB) | Platelets, endothelial cells, macrophages, smooth muscle cells | Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis |
| TGF (α–β) | Macrophages, Tlymphocytes, keratinocytes | Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation |
| VEGF | Platelets, macrophages, keratinocytes, endothelial cells | Increases angiogenesis and vessel permeability, stimulates mitogenesis for endothelial cells |
| EGF | Platelets, macrophages, monocytes | Proliferation of keratinocytes, fibroblasts, stimulates mitogenesis for endothelial cells |
| (a-b)-FGF | Platelets, macrophages, mesenchymal cells, chondrocytes, osteoblasts | Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts |
| CTGF | Platelets, fibroblasts | Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion |
| IGF-1 | Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix | Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts |
| HGF | Platelets, mesenchymal cells | Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing |
| KGF | Fibroblasts, mesenchymal cells | Regulates epithelial migration and proliferation |
| Ang-1 | Platelets, neutrophils | Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte |
| PF4 | Platelets | Calls leucocytes and regulates their activation. Microbiocidal activities |
| SDF-1α | Platelets, endothelial cells, fibroblasts | Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes |
| TNF | Macrophages, mast cells, T lymphocytes | Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis |
In hair treatment, PRP stimulates hair follicles, thus encouraging hair growth and improving hair thickness.
PRP is injected into the targeted areas of the scalp, which is thought to activate dormant hair follicles and promote a healthier hair growth cycle.
In this process whole blood is separated into the bottom red coloured part that is mainly Red Blood Cells and top part plasma which is rich platelets also called PRP.
The growth factors and other cytokines present in PRP include:
Treatment Plan
| PGF and Cytokines | Cell0 Sources | Function and Effects |
| PDGF (AA-BB-AB) | Platelets, endothelial cells, macrophages, smooth muscle cells | Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis |
| TGF (α–β) | Macrophages, Tlymphocytes, keratinocytes | Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation |
| VEGF | Platelets, macrophages, keratinocytes, endothelial cells | Increases angiogenesis and vessel permeability, stimulates mitogenesis for endothelial cells |
| EGF | Platelets, macrophages, monocytes | Proliferation of keratinocytes, fibroblasts, stimulates mitogenesis for endothelial cells |
| (a-b)-FGF | Platelets, macrophages, mesenchymal cells, chondrocytes, osteoblasts | Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts |
| CTGF | Platelets, fibroblasts | Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion |
| IGF-1 | Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix | Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts |
| HGF | Platelets, mesenchymal cells | Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing |
| KGF | Fibroblasts, mesenchymal cells | Regulates epithelial migration and proliferation |
| Ang-1 | Platelets, neutrophils | Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte |
| PF4 | Platelets | Calls leucocytes and regulates their activation. Microbiocidal activities |
| SDF-1α | Platelets, endothelial cells, fibroblasts | Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes |
| TNF | Macrophages, mast cells, T lymphocytes | Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis |
| PGF and Cytokines | Cell0 Sources | Function and Effects |
| PDGF (AA-BB-AB) | Platelets, endothelial cells, macrophages, smooth muscle cells | Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis |
| TGF (α–β) | Macrophages, Tlymphocytes, keratinocytes | Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation |
| VEGF | Platelets, macrophages, keratinocytes, endothelial cells | Increases angiogenesis and vessel permeability, stimulates mitogenesis for endothelial cells |
| EGF | Platelets, macrophages, monocytes | Proliferation of keratinocytes, fibroblasts, stimulates mitogenesis for endothelial cells |
| (a-b)-FGF | Platelets, macrophages, mesenchymal cells, chondrocytes, osteoblasts | Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts |
| CTGF | Platelets, fibroblasts | Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion |
| IGF-1 | Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix | Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts |
| HGF | Platelets, mesenchymal cells | Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing |
| KGF | Fibroblasts, mesenchymal cells | Regulates epithelial migration and proliferation |
| Ang-1 | Platelets, neutrophils | Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte |
| PF4 | Platelets | Calls leucocytes and regulates their activation. Microbiocidal activities |
| SDF-1α | Platelets, endothelial cells, fibroblasts | Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes |
| TNF | Macrophages, mast cells, T lymphocytes | Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis |