PGF and Cytokines Cell0 Sources Function and Effects
PDGF (AA-BB-AB) Platelets, endothelial cells, macrophages, smooth muscle cells Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis
TGF (α–β) Macrophages, Tlymphocytes, keratinocytes Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation
VEGF Platelets, macrophages, keratinocytes, endothelial cells Increases angiogenesis and vessel permeability, stimulates mitogenesis for endothelial cells
EGF Platelets, macrophages, monocytes Proliferation of keratinocytes, fibroblasts, stimulates mitogenesis for endothelial cells
(a-b)-FGF Platelets, macrophages, mesenchymal cells, chondrocytes, osteoblasts Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts
CTGF Platelets, fibroblasts Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion
IGF-1 Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts
HGF Platelets, mesenchymal cells Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing
KGF Fibroblasts, mesenchymal cells Regulates epithelial migration and proliferation
Ang-1 Platelets, neutrophils Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte
PF4 Platelets Calls leucocytes and regulates their activation. Microbiocidal activities
SDF-1α Platelets, endothelial cells, fibroblasts Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes
TNF Macrophages, mast cells, T lymphocytes Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis
PGF and Cytokines Cell0 Sources Function and Effects
PDGF (AA-BB-AB) Platelets, endothelial cells, macrophages, smooth muscle cells Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis
TGF (α–β) Macrophages, Tlymphocytes, keratinocytes Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation
VEGF Platelets, macrophages, keratinocytes, endothelial cells Increases angiogenesis and vessel permeability, stimulates mitogenesis for endothelial cells
EGF Platelets, macrophages, monocytes Proliferation of keratinocytes, fibroblasts, stimulates mitogenesis for endothelial cells
(a-b)-FGF Platelets, macrophages, mesenchymal cells, chondrocytes, osteoblasts Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts
CTGF Platelets, fibroblasts Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion
IGF-1 Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts
HGF Platelets, mesenchymal cells Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing
KGF Fibroblasts, mesenchymal cells Regulates epithelial migration and proliferation
Ang-1 Platelets, neutrophils Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte
PF4 Platelets Calls leucocytes and regulates their activation. Microbiocidal activities
SDF-1α Platelets, endothelial cells, fibroblasts Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes
TNF Macrophages, mast cells, T lymphocytes Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis

PRP - Platelet Rich Plasma

how-prp-works-for-hair-treatment
How PRP Works for Hair Treatment?

In hair treatment, PRP stimulates hair follicles, thus encouraging hair growth and improving hair thickness.

PRP is injected into the targeted areas of the scalp, which is thought to activate dormant hair follicles and promote a healthier hair growth cycle.

In this process whole blood is separated into the bottom red coloured part that is mainly Red Blood Cells and top part plasma which is rich platelets also called PRP.

regular-prp
Regular PRP :
  1. The PRP tubes contain a thixotropic gel that separates the supernatant plasma from the cellular components, allowing to obtain autologous plasma of a powerful therapeutic effect.

  2. There are three general categories of preparation of PRP based on its leukocyteand fibrin content

  3. Leukocyte-rich PRP (L-PRP), leukocyte reduced PRP (P-PRP; leukocyte reduced or pure PRP), leukocyte platelet-rich fibrin. The platelets collected in PRP can be activated by the addition of thrombinor calcium chloride, which induces the release of the mentioned factors from alpha granules

The growth factors and other cytokines present in PRP include:

Treatment Plan

  • Regular PRP therapy Needs 3-4 sessions which are done at intervals of one month. 
  • Regular PRP is also used as a maintenance treatment for hair loss and hair thinning at intervals of every 3 months
A partial list of PRP-based growth factors and platelet cytokines with their cell sources.
PGF and Cytokines Cell0 Sources Function and Effects
PDGF (AA-BB-AB) Platelets, endothelial cells, macrophages, smooth muscle cells Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis
TGF (α–β) Macrophages, Tlymphocytes, keratinocytes Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation
VEGF Platelets, macrophages, keratinocytes, endothelial cells Increases angiogenesis and vessel permeability, stimulates mitogenesis for endothelial cells
EGF Platelets, macrophages, monocytes Proliferation of keratinocytes, fibroblasts, stimulates mitogenesis for endothelial cells
(a-b)-FGF Platelets, macrophages, mesenchymal cells, chondrocytes, osteoblasts Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts
CTGF Platelets, fibroblasts Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion
IGF-1 Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts
HGF Platelets, mesenchymal cells Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing
KGF Fibroblasts, mesenchymal cells Regulates epithelial migration and proliferation
Ang-1 Platelets, neutrophils Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte
PF4 Platelets Calls leucocytes and regulates their activation. Microbiocidal activities
SDF-1α Platelets, endothelial cells, fibroblasts Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes
TNF Macrophages, mast cells, T lymphocytes Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis
PGF and Cytokines Cell0 Sources Function and Effects
PDGF (AA-BB-AB) Platelets, endothelial cells, macrophages, smooth muscle cells Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis
TGF (α–β) Macrophages, Tlymphocytes, keratinocytes Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation
VEGF Platelets, macrophages, keratinocytes, endothelial cells Increases angiogenesis and vessel permeability, stimulates mitogenesis for endothelial cells
EGF Platelets, macrophages, monocytes Proliferation of keratinocytes, fibroblasts, stimulates mitogenesis for endothelial cells
(a-b)-FGF Platelets, macrophages, mesenchymal cells, chondrocytes, osteoblasts Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts
CTGF Platelets, fibroblasts Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion
IGF-1 Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts
HGF Platelets, mesenchymal cells Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing
KGF Fibroblasts, mesenchymal cells Regulates epithelial migration and proliferation
Ang-1 Platelets, neutrophils Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte
PF4 Platelets Calls leucocytes and regulates their activation. Microbiocidal activities
SDF-1α Platelets, endothelial cells, fibroblasts Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes
TNF Macrophages, mast cells, T lymphocytes Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis
Book Consultation