PGF and Cytokines |
Cell0 Sources |
Function and Effects |
PDGF (AA-BB-AB) |
Platelets, endothelial cells, macrophages,
smooth muscle cells |
Mitogenic for mesenchymal cells and osteoblasts, stimulates chemotaxis and mitogenesis in fibroblast/ glial/smooth muscle cells, regulates collagenase secretion and collagen synthesis, stimulates macrophage and neutrophil chemotaxis |
TGF (α–β) |
Macrophages, Tlymphocytes, keratinocytes |
Stimulates undifferentiated mesenchymal cell proliferation; regulates endothelial, fibroblastic, and osteoblastic mitogenesis; regulates collagen synthesis and collagenase secretion; regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis; inhibits macrophage and lymphocyte proliferation |
VEGF |
Platelets, macrophages, keratinocytes, endothelial cells |
Increases angiogenesis and vessel permeability,
stimulates mitogenesis for endothelial cells |
EGF |
Platelets, macrophages, monocytes |
Proliferation of keratinocytes, fibroblasts,
stimulates mitogenesis for endothelial cells |
(a-b)-FGF |
Platelets, macrophages, mesenchymal cells,
chondrocytes, osteoblasts |
Promotes growth and differentiation of chondrocytes and osteoblasts; mitogenic for mesenchymal cells, chondrocytes, and osteoblasts |
CTGF |
Platelets, fibroblasts |
Promotes angiogenesis, cartilage regeneration, fibrosis, and platelet adhesion |
IGF-1 |
Platelets, plasma, epithelial cells, endothelial cells, fibroblasts, osteoblasts, bone matrix |
Chemotactic for fibroblasts and stimulates protein synthesis. Enhances bone formation by proliferation and differentiation of osteoblasts |
HGF |
Platelets, mesenchymal cells |
Regulates cell growth and motility in epithelial/endothelial cells, supporting epithelial repair and neovascularization during wound healing |
KGF |
Fibroblasts, mesenchymal cells |
Regulates epithelial migration and proliferation |
Ang-1 |
Platelets, neutrophils |
Induces angiogenesis stimulating migration and proliferation of endothelial cells. Supports and stabilizes blood vessel development via the recruitment of pericyte |
PF4 |
Platelets |
Calls leucocytes and regulates their activation. Microbiocidal activities |
SDF-1α |
Platelets, endothelial cells, fibroblasts |
Calls CD34+ cells, induces their homing, proliferation and differentiation into endothelial
progenitor cells stimulating angiogenesis. Calls mesenchymal stem cells and leucocytes |
TNF |
Macrophages, mast cells,
T lymphocytes |
Regulates monocyte migration, fibroblast proliferation, macrophage activation, angiogenesis |